Alphaparin

What is it?

An antithrombotic, Low Molecular Weight Heparin (LMWH) comprising 3000iu certoparin with anti-Factor Xa activity. Available as a solution in a pre-filled syringe for use in hospital.

Medical Uses

Prevention of venous thromboembolism during and after surgery.

Dosage

Adults: 1 dose (3000iu) given by subcutaneous injection into peritoneal fold 1 to 2 hours before operation is performed. Thereafter, one dose daily for a further 7 to 10 days or until the patient is sufficiently recovered to walk about.

Special Care

Patients having spinal anaesthesia or epidural; there is a risk of bleeding and paralysis - platelets must be monitored.

Avoid Use

Serious bleeding disorders, severe liver or kidney dysfunction, sensitivity to heparin, active stomach or gastrointestinal ulcer, bacterial endocarditis (inflammation and infection of the endocardia, the lining of the chambers of the heart and of the valves), severe high blood pressure.

Possible Drug and Food Interactions

Digitalis, oral anticoagulants, dextran, NSAIDs, dipyridamole, cytostatic drugs, tetracycline antibiotics, ethacrynic acid, antihistamines.

Known Side Effects

Bleeding at injection site, allergic reactions, thrombocytopaenia (an abnormality affecting blood platelets), hyperaldosteronism (a dysfunction of the adrenal glands) causing elevated levels of potassium in blood. Potassium levels must be monitored, especially in those receiving extended treatment or patients with diabetes or acidosis, kidney failure or those who have had potassium-sparing drugs.