Bondronat

What is it?

A biphosphonate which affects bone metabolism by reducing the activity of osteoclasts - cells which are involved in the process of bone resorption and Also, the dissolving of crystals of calcium apatite. Contains 2mg of ibandronic acid per 2ml as a solution for infusion.

Medical Uses

Moderate to severe hypercalcaemia (high levels of blood calcium) caused by the presence of a tumour, in which secondary growths may or may not be present.

Dosage

Adults; moderate hypercalcaemia, 2mg given over 2 hours by intravenous infusion. Severe hypercalcaemia, 4mg given over 2 hours by intravenous infusion.

Special Care

Must be given under supervision of specialist physician. Patient must be kept fully hydrated and blood calcium, phosphate and magnesium levels require careful monitoring as does kidney function. Special care where there is known history of allergy to aspirin or other anti-inflammatory drug and in heart failure.

Avoid Use

Children, pregnant and breastfeeding women, serious liver or kidney disease.

Possible Drug and Food Interactions

Aminoglyeosides.

Known Side Effects

Disordered blood chemistry, low blood calcium levels, pain in bones, feverishness and 'flu-like symptoms, malaise. Rarely, short-lived swellings, bronchospasm. Any adverse side effects must be reported to the Committee on the Safety of Medicines.