Bonefos

What is it?

A preparation of the drug, sodium clodronate (a diphosphonate) which affects bone metabolism, preventing the increased rate of bone turnover associated with certain malignant conditions. Bonefos is available in the form of capsules, tablets and as a solution for intravenous infusion. Yellow capsules contain 400mg and the white, oval-shaped film- coated tablets contain 800mg. These are marked L134 and scored. The intravenous solution contains 60mg per ml in 5ml ampoules.

Medical Uses

Hypercalcaemia of malignancy. Bone pain and lesions associated with secondary bone growths as a result of multiple myeloma (malignant bone marrow disease) or breast cancer.

Dosage

Adults, capsules or tablets, 1600mg each day either as one or two doses, taken 1 hour before or 1 hour after a meal. The maximum dose is 3200mg. Infusion, adults, 1500mg as single infusion over 4 hours or 300mg given by slow intravenous infusion for up to 7 days. Afterwards, capsules or tablets should be taken.

Special Care

Moderate kidney disorders. Ensure adequate fluid intake, monitor blood calcium levels and kidney function.

Avoid Use

Children, pregnancy, breast- feeding, severe kidney failure.

Possible Drug and Food Interactions

Other biphosphonates, NSAIDs, mineral supplements, antacid preparations.

Known Side Effects

Gastrointestinal upset, disturbance of kidney function, parathyroid hormone, lactic acid dehydrogenase, creatinine, transaminase, alkaline phosphatase (enzymes) levels may be elevated for a time. Rarely, there may be hypocalcaemia which does not cause symptoms or skin reactions.