Copaxone

What is it?

An immunomodulator available as a powder with a solution for reconstitution and injection. When reconstituted, it provides 20mg of glatiramer as acetate per ml.

Medical Uses

Reduction in frequency of relapse in patients with multiple sclerosis who are able to walk, who have experienced at least one relapse in the last 2 years.

Dosage

Adults, 20mg by subcutaneous injection once each day.

Special Care

Treatment must be started under supervision of experienced, skilled physician; elderly, pregnancy, breastfeeding, kidney disorders, previous cardiovascular disease. Kidney function should be monitored and patients observed for signs of allergic response to injection.

Avoid Use

Children, patients with allergy to mannitol.

Possible Drug and Food Interactions

Protein-bound drugs, corticosteroids.

Known Side Effects

Immediate sensitivity reactions following injection eg reactions at injection site, raised heartbeat, sweating, rash, palpitations, trembling, swelling of face, hands, feet, headache, nausea, trembling, fainting, muscle pain, breathlessness, lymphadenopathy, weakness, hypertonia (abnormal increase in muscle tone), dilation of blood vessels. Any adverse side effects must be reported to the Committee on the Safety of Medicines (CSM).

Manufacturer

Aventis/Teva.