Cozaar-Comp

What is it?

An antihypertensive angiotensin II antagonist with thiazide available as losartan potassium (50mg) and hydrochlorothiazide (12.Smg) in oval, yellow, film-coated tablets marked 717.

Medical Uses

Hypertension in ppatients who have been controlled on these 2 drugs given separately.

Dosage

Start with 1 per day; maximum 2 per day if necessary.

Special Care

Systemic lupus erythematdsus (inflammatory disorder), cardiomyopathy, gout, obstructive valvular disease. Blood levels of electrolytes should be monitored

Avoid Use

Children, pregnancy, breastfeeding, liver or kidney disease, dialysis, anuria (absence of urination), depleted intravascular volume.

Possible Drug and Food Interactions

NSAIDs, muscle relaxants, rifampicin, narcotics, barbiturates, fluconazole, ACTH, lithium, adrenaline, corticosteroids, eolestipol, cholestyramine, potassium-sparing diuretics, drugs for diabetes.

Known Side Effects

Angioederna, gastrointestinal upset, dizziness, rash, effects upon standing. In rare cases, hepatitis, angioedema, anaemia, cough, anaphylactic effects. All adverse side effects should be reported to the Committee on the Safety of Medicines (CSM).

Manufacturer

M.S.D.