Daonil

What is it?

A sulphonylurea, available as white oblong tablets containing 5mg of glibenclamide marked LDI and with symbol. Also, SEMI-DAONIL available as white, scored tablets containing 2.5mg of glibenclamide.

Medical Uses

Type 2 diabetes (formerly, Non-Insulin-Dependent Diabetes Mellitus, NIDDM).

Dosage

Adults, 5mg each day at breakfast at first increasing gradually by 2.5 to 5mg each week to a maximum of 15mg. Consult manufacturer's instructions.

Special Care

Kidney failure, the elderly.

Avoid Use

Pregnancy, breastfeeding, juvenile, growth-onset or unstable brittle diabetes (all forms of insulin-dependent diabetes mellitus), severe liver or kidney disease, ketoacidosis, stress, infections, surgery, endocrine disorders.

Possible Drug and Food Interactions

Risk of hypoglycaemia with: sulfonamides, fibrates, fluconazole, aspirin, alcohol, chloramphenicol, MAOIs, NSAIDs, miconazole, oral anticoagulants, β-blockers, ACE inhibitors, probenecid, phenylbutazone, cimetidine. Risk of hyperglycaemia with: diuretics, progestogens, oestrogens, contraceptive pills, phenothiazines, derivatives of nicotinic acid, thyroid hormones, phenytoin, danazol, sympathomimetics, calcium antagonists, corticosteroids, isoniazid.

Known Side Effects

Allergic reactions including skin rash, hypoglycaemia, disturbance of vision, liver disorders, gastrointestinal effects, headache, abdominal pains, malaise, blood effects, trembling, dizziness, raised liver enzymes, confusion, drowsiness.