Diamox

What is it?

A diuretic preparation which is a carbonic anhydrase inhibitor available as scored, white tablets containing 250mg of acetazolamide marked LEDERLE 4395. Also, DIAMOX SR, available as sustained-release, orange capsules containing 250mg of acetazolamine.

Medical Uses

Diamox, congestive heart failure and oedema, epilepsy, glaucoma. Diamox SR, glaucoma.

Dosage

Adults, Diamox, for heart failure, oedema: 250-375mg to start, each morning or on alternate days. For premenstrual oedema, 125-375mg in 1 dose taken 5 to 10 days before menstruation. For epilepsy, adults, 2501000mg each day in divided doses. Epilepsy, children, 8 to 30mg per kg of body weight each day in divided doses to a maximum of 750mg. For glaucoma, adults, 250-1000mg each day in divided doses. Children, 125750mg daily; infants, 125mg daily. Diamox SR, adults, glaucoma, 1 to 2 tablets each day.

Special Care

Breastfeeding, emphysema, pulmonary obstruction. Monitoring of blood, electrolytes and fluid is required. Any unusual rashes to be reported to doctor.

Avoid Use

Children, except for epilepsy, pregnancy, certain kidney conditions, chronic closed angle glaucoma, adrenal insufficiency, hypersensitivity to sulfonamides, depletion of sodium or potassium. Also, for glaucoma treatment liver impairment.

Possible Drug and Food Interactions

Oral anticoagulants, hypoglycaemics, folic acid antagonists.

Known Side Effects

Headache, drowsiness, thirst, flushing, polyuria, blood changes, rash, metabolic acidosis, paraesthesia (tingling, 'pins and needles').

Manufacturer

Goldshield.