Elleste Duet 1mg

What is it?

A hormonal, HRT preparation containing oestrogen and progestogen, comprising a pack of film- coated tablets. 16 white tablets each contain 1mg of oestradiol, marked 01; 12 green tablets contain 1mg of oestradiol and 1mg of norethisterone acetate, each marked P1. Also, ELLESTE DUET 2mg, comprising a course of film-coated tablets. 16 orange ones contain 2mg of oestradiol marked 02 and 12 grey ones contain 2mg of oestradiol and 1mg of norethisterone acetate, marked P2.Usedfor: menopausal symptoms; Elleste duet is additionally used to prevent osteoporosis following the menopause.

Dosage

Adult women, start course with 1 white or l orange tablet (depending upon preparation being used), waiting for 1st day of cycle if applicable, then follow with either the green or the grey tablets. Continue to take the tablets without a break, as directed by doctor.

Special Care

Patients considered to be at risk of thrombosis, those with diabetes, epilepsy, hypertension, multiple sclerosis, migraine, fibroids in uterus, fibrocystic disease, breast nodules, osteosclerosis, tetany, liver disease (monitor liver function), porphyria, kidney disorder, cholelithi- asis. All this group should be monitored closely. Regular examination of breasts and pelvic organs should be carried out and blood pressure checked. Persistent breakthrough bleeding. Women should self-examine breasts, attend for mammography (if applicable) and have cervical smear tests.

Avoid Use

Pregnancy, breast-feeding, hormone-dependent cancers, breast or uterus cancer, endometriosis, undiagnosed vaginal bleeding. Serious heart, kidney or liver disease, thrombophlebitis and thromboembolic diseases. Patients suffering from Dublin- Johnson syndrome or Rotor syndrome.

Possible Drug and Food Interactions

Drugs which induce liver enzymes.

Known Side Effects

Weight gain, enlargement and tenderness of breasts, fluid retention, cramps, gastro-intestinal upset, nausea and vomiting, headaches, breakthrough bleeding, dizziness. Cholestatic jaundice, effects on liver function, migraine, nose bleeds, worsening of varicose veins, lowered glucose tolerance, itching and reddening of skin (usually short-lived). Withdraw if migraines or other severe headaches occur for first time, or serious vision disturbances, signs of thromboembolic disorders, seizures, jaundice, hepatitis, serious, whole body itching, pregnancy. Stop 6 weeks before planned surgery or prolonged immobilisation.