Endoxana

What is it?

An alkylating eytotoxic drug produced as a powder in vials containing 200mg, 500mg or 1g of cyclophosphamide, for reconstitution and injection. It is Also, available as white sugarcoated tablets (50mg).

Medical Uses

Malignant diseases e. g. lymphoma, leukaemia and some solid tumours.

Dosage

Adults, taken with Uromitexan as directed by physician skilled in cancer chemotherapy.

Special Care

Patients with diabetes, elderly or debilitated persons.

Avoid Use

Children, pregnancy, breastfeeding, myelosuppression (suppression of production of blood cells in the bone marrow), blood in urine, damage to lining of urinary tract, acute urinary tract infections.

Possible Drug and Food Interactions

Sulphonylureas, radiotherapy, doxorubicin, other chemotherapeutic agents, suxamethonium, allopurinol

Known Side Effects

Vomiting, hair loss, nausea, bone marrow suppression and suppression of the reticulo-endothelial system, toxic effects on heart and urinary tract, haematuria (blood in urine), male sterility (Azoospermiaa lack of spermaztozoa in the semen), amenorrhoea (cessation/absence of menstruation).

Manufacturer

Baxter Oncology.