Floxapen

What is it?

A penicillinase-resistant form of penicillin. (Penicillinase is an enzyme produced by some bacteria that renders penicillin inactive, hence the infection being treated will be resistant to the antibiotic. ) Floxapen is produced in several forms: black/ caramel-coloured capsules of 2 strengths containing 250mg and 500mg flucloxacillin sodium, each marked with strength and name. FLOXAPEN SYRUP contains 125mg or 250mg flucloxacillin (as magnesium salt) per 5ml, supplied as powder for reconstitution with water to make 100ml. FLOXAPEN INJECTION is supplied as powder in vials for reconstitution at strengths of 250mg, 500mg and lg flucloxacillin (as sodium salt).

Medical Uses

Ear, nose, throat, soft tissue, skin infections caused by gram positive bacteria, other infections including those caused by staphylococci bacteria resistant to penicillin.

Dosage

Adults, capsules and syrup, 250mg 4 times each day taken 1 hour to half an hour before meals. Osteomyelitis and endoearditis, up to 8g in divided doses each day, every 6 to 8 hours. Injection, 250mg-lg given intravenously 4 times each day. Children, capsules, syrup and injection, age 2 years and under, quarter of adult dose; age 2 to 10 years, half adult dose; over 10 years, adult dose.

Known Side Effects

Gastrointestinal upset, allergic responses; rarely, pseudomembranous colitis, cholestatic jaundice, hepatitis.

Manufacturer

Glaxosmithkline.