Glurenorm

What is it?

An antidiabetic drug belonging to the group known as sulphonyluress, available as scored, white tablets containing 30mg gliquidxne and marked G.

Medical Uses

Type II diabetes.

Dosage

Adults, in the order of 45-60mg each day in divided doses before meals. Maximum dose is 180mg each day.

Special Care

Kidney failure, the elderly.

Avoid Use

Pregnancy, breastfeeding, juvenile, growth-onset or unstable brittle diabetes (all forms of insulin- dependent diabetes mellitus), severe liver or kidney disease, ketoacidosis, stress, infections, surgery, endocrine disorders. Also, porphria (an inherited metabolic disorder involving porphyrins).

Possible Drug and Food Interactions

Risk of hypoglycaemia with: sulfonamides, fibrates, fluconazole, aspirin, alcohol, chloramphenicol, MAOIs, NSAIDs, miconazole, oral anticoagulants, β-blockers, ACE inhibitors, probenecid, phenylbutazone, cimetidine. Risk of hyperglycemia with: diuretics, progestogens, oestrogens, contraceptive pills, phenothiazines, derivatives of nicotinic acid, thyroid hormones, phenytoin, danazol, sympathomimetics, calcium antagonists, corticosteroids, isoniazid.

Known Side Effects

Allergic reactions including skin rash, hypoglycemia, disturbance of vision, liver disorders, gastrointestinal effects, headache, abdominal pains, malaise, blood effects, trembling, dizziness, raised liver enzymes, confusion, drowsiness.