Glypressin

What is it?

A vasopressin analogue (ie a synthetic copy of antidiuretic hormone, ADH, secreteted by the pituitary gland, which reduces urine production by increasing the amount of water reabsorbed by the kidneys). It is produced as a powder in vials containing 1mg terlipressin, along with diluent, for reconstitution and injection.

Medical Uses

Bleeding varicose veins in the oesophagus.

Dosage

Adults, 2mg given by intravenous bolus injection (a dose given all at once) followed by further 1 or 2mg doses every 4, 5 or 6 hours for a maximum period of 72 hours.

Special Care

Patients with various heart conditions including weak heart, arrhythmias, and Also, serious atherosclerosis or hypertension. Blood levels of electrolytes (salts), fluid balance and blood pressure require careful monitoring.

Avoid Use

Children, pregnancy.

Known Side Effects

Hypertension, paleness (short-lived), headache, cramps in abdomen.

Manufacturer

Ferring.