Humulin M

What is it?

Combined preparations of soluble human insulin (prb) and isphane insulin in various ratios, 100iu. per ml. Available in the following ratios: HUMULIN M2: 20% soluble humaninsulin: 80% isophane insulin. HUMULIN M3: 30% soluble humaninsulin: 70% isophane insulin. HUMULIN M5: 50% soluble humaninsulin: 50% isophane insulin. Available in cartridges for use with Autopen (M2 and M3 only); Humaject preloaded pen (M3 only); Humapen, or in vials (M3 and M5 only).

Medical Uses

Diabetes.

Dosage

According to individual patient requirements, usually self-administered by subcutaneous or intramuscular injection.

Special Care

Kidney or liver disease, patients transferring from animal insulins (should be warned that early signs of hypoglycaemia may not be so apparent). Infections, illnesses, stress, emotional upset, pregnancy, change in insulin source, type etc; in all these cases, dose adjustments may be needed.

Possible Drug and Food Interactions

Oral contraceptives, MAO's, alcohol, β-blockers, corticotrophin, diuretics, corticosteroids.

Known Side Effects

Lipodystrophy (changes involving fat deposition) at injection site.

Manufacturer

Lilly.