Hypovase

What is it?

An antihypertensive preparation which is a selective ai-blocker. It is produced as tablets of various strengths all containing prazosin hydrochloride. White 500µg tablets marked Pfizer; scored, orange 1mg tablets marked HYP/1; scored, white 2mg tablets marked HYP/2 and Pfizer.

Medical Uses

Congestive heart failure, high blood pressure, Raynaud's phenomenon, additional therapy in the treatment of urinary tract obstruction when the cause is benign enlargement of the prostate gland.

Dosage

Adults, congestive heart failure, 500µg, 2, 3 or 4 times each day in first instance, increasing to 4mg in divided doses each day. Then a usual maintenance dose in the order of 4-20mg in divided doses. Hypertension, 500µg as evening dose at first, followed by 500µg 2 or 3 times each day for a period of 3 days to l week. Then, Img 2 or 3 times each day for 3 days to 1 week. The dose may be further increased gradually as required with a daily maximum of 20mg, as divided doses. Raynaud's phenomenon, 500µg as starting dose in evening, followed by 500µg twice each day for 3 days to 1 week, adjusted according to response. Then a maintenance dose of 1 or 2mg twice each day. Additional therapy in urine obstruction, 500µg taken as evening dose at first, then 500mg twice each day for 3 days to 1 week, adjusted according to response. Usual maintenance dose of 2mg twice each day.

Special Care

Pregnancy, breastfeeding, elderly persons, patients suffering from congestive heart failure caused by stenosis (narrowing of arteries), subject to fainting while passing urine.

Avoid Use

Children.

Possible Drug and Food Interactions

Other anti-hyperten sive drugs.

Known Side Effects

Dry mouth, dizziness on rising from lying down (postural hypotension), fluid retention, headache, nausea, blocked, stuffy nose, palpitations, impotence, diarrhoea, weariness, skin rash, blurring of vision.