Kinidin Durules

What is it?

A class f antiarrhythmic preparation available as white, sustamed-release tablets containing 250mg of quinidine bisulphate.

Medical Uses

Heart arrhythmias - suppression of ventricular and supraventricular rapid arrhythmias, maintenance of sinus rhythm after cardioversion of atrial fibrillation.

Dosage

Adults, 1 tablet each day at first increasing to 2 to 5 daily.

Special Care

Slow heartbeat, intestinal obstruction, heart shock, low blood pressure, prolonged AV conduction, low blood potassium levels, sustained heart decompensation. After first dose is given, patient should be monitored for allergic reactions.

Avoid Use

Children, pregnancy, heart block, myasthenia gravis, inflammation or damage of heart muscle, uncompensated heart failure, toxic effects of digitalis, incomplete AV block, thrombocytopenia caused by quinidine.

Possible Drug and Food Interactions

Cimetidine, nifedipine, coumarin anticoagulants, metoprolol, verapamil, barbiturates, desipramine, digitoxin, procainamide, non-depolarizing substances, imipramine, digoxin, rifampicin, phenytoin, amiodarone.

Known Side Effects

Allergic responses, cinchonism (a condition resulting from overdose of quinine and quinidine characterized by ringing in the ears, deafness, headache, brain congestion), gastrointestinal upset, low blood pressure, slow heartbeat.