Naprosyn SR

What is it?

A propionic acid, available as white, scored, film-coated, capsule- shaped tablets containing 500mg of naproxen as sodium salt, marked 500. Also, NAPROSYN EC, available as enteric-coated, white tablets in 3 strengths containing 250mg, 375mg and 500mg of naproxen, marked NPR EC 250, Naprosyn EC and NPR EC 500, respectively. Also, NAPROSYN TABLETS, available as scored, buff- coloured tablets in 2 strengths containing 250mg of naproxen, marked NPR LE 250 and oval-shaped tablets containing 500mg of naproxen, marked NPR LE 500.

Medical Uses

Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, musculoskeletal disorders, acute gout, dysmenorrhea (painful periods).

Dosage

Adults, Naprosyn SR, 1 or 2 tablets once each day swallowed whole; Naprosyn EC, Naprosyn tablets, 500 to 1000mg each day either as single dose taken at night or in the morning or as 2 divided doses at 12 hour intervals. For gout, 750mg at first then 250mg every 8 hours; for musculoskeletal disorders and dysmenorrhoea, 500mg to start with and then 250mg every 6 to 8 hours, as needed to a maximum of 1250mg daily after first day of treatment. Children, for juvenile rheumatoid arthritis (JRA) only, use Naprosyn tablets and Naprosyn EC only, aged 5 to 16 years, 10mg per kg of body weight each day in 2 divided doses at 12 hour intervals.

Special Care

Elderly, liver or kidney damage, heart failure, asthma, a history of gastro-intestinal lesions. Patients being treated long-term require monitoring.

Avoid Use

Pregnancy, breastfeeding, stomach ulcer, allergy caused by aspirin or anti-inflammatory drugs.

Possible Drug and Food Interactions

Ace inhibitors, corticosteroids, β-blockers, lithium, mifepristone, cardiac glycosides, anticoagulants, adrenal function tests, cyclosporin, quinolones, sulphonylureas, hydantoins, frusemide, methotrexate, diuretics, probenecid.