Norimin

What is it?

A combined oestrogen/progestogen contraceptive available as white tablets containing 35µg of ethinyloestradiel and 1mg of norethisterene tablet marked BX and SEARLE.

Medical Uses

Oral contraception.

Dosage

1 tablet each day for 21 days, starting on 1st day of menstruation, then 7 days without tablets.

Special Care

Hypertension, severe kidney disease receiving dialysis, Raynaud's disease, diabetes, multiple sclerosis, asthma, varicose veins, elevated levels of prolrrctin (a hormone) in the blood (hyperprolactinemia). Risk of thrombosis increases with smoking, age and obesity. Blood pressure, breasts and pelvic organs should be checked during period of treatment.

Avoid Use

Pregnancy, heart and circulatory diseases, angina, sickle cell anaemia, pulmonary hypertension. Also, hormone-dependent cancers, undiagnosed vaginal bleeding, chorea, liver disease, history of cholestatic jaundice of pregnancy, infectious hepatitis, Dublin-Johnson syndrome, Rotor syndrome, recent hyperprolactinemia disease.

Possible Drug and Food Interactions

Phenytoin, carbamazepine, tetracyclines, primidone, chloral hydrate, glutethimide, phenylbutazone, rifampicin, griseofulvin, ampicillin, dichloralphenazone, ethosuximide, barbiturates, St John's Wort.

Known Side Effects

Feeling of bloatedness due to fluid retention, leg pains, breast enlargement, erosion of cervix, muscular cramps, weight gain, breakthrough bleeding, depression, headaches, vaginal discharge, loss of libido, nausea, brown patches on skin (chloasma). Stop drug immediately in event of pregnancy, if frequent, severe headaches occur or signs of thromboses, severe pain in upper abdominal region, enlarged liver, jaundice, rise in blood pressure, severe depression, increased number of fits. Drug should be discontinued 6 weeks before major planned surgery and restarted 2 weeks afterwards, as long as woman is fully mobile. Should be discontinued during long periods of immobility.