Novonorm

What is it?

An oral hypoglycaemic drug which is a prandial glucose regulator (regulates glucose taken in at mealtimes). Available in tablets of 3 different strengths, all containing repaglinide; white tablets contain 0.5mg; yellow tablets contain 1mg; peach tablets contain 2mg. All are marked with logo.

Medical Uses

Type II diabetes which has failed to be controlled by diet and exercise measures alone. Can Also, be combined with metformin if control is inadequate.

Dosage

Adults aged over 18 years, 0.5mg 3 times each day, taken quarter of an hour before each main meal, to start with. Dose can then be increased at 1 to 2 week intervals, according to response to a maximum single dose of 4mg before each main meal. The daily maximum intake is 16mg. If changing from another oral hypoglycaemic drug, the starting dose should be 1mg, taken as above.

Special Care

Blood glucose should be monitored and glycosylated haemoglobin checked periodically.

Avoid Use

Children, elderly patients aged over 75 years, pregnancy, breast- feeding, Type I diabetes, diabetic acidosis, liver disease.

Possible Drug and Food Interactions

Cortieosteroids, rifampicin, MAOIs, NSAIDs, anabolic steroids, ACE inhibitors, danazol, simvastatin, thyroid hormones, salicylates, β-blockers, octreotide, oral contraceptives, alcohol, sympgthomimetics, thigzide diuretics.

Known Side Effects

Gastrointestinal upset, hypoglycaemia, rash, pains in abdomen, disturbance of vision, short-lived rise in liver enzymes. Any adverse side effects should be reported to the Committee on the Safety of Medicines (CSM).