Oxynorm cd

What is it?

An opiod and controlled drug available as capsules in 3 different strengths, all containing oxycodone hydrochloride. Beige/orange contain 5mg; beige/white contain 10mg; beige/pink contain 20mg. All are marked with strength and ONR. Also, OXYNORM LIQUID, containing 5mg of oxycodone hydrochloride per 5ml. Also, OXYNORM CONCENTRATE, containing 10mg of oxycodone hydrochloride per ml.

Medical Uses

Moderate to severe pain, postoperative and caused by cancer.

Dosage

Adults, new to opiods or pain not controlled by weaker opiods, start with 5mg every 4 to 6 hours, then increase, once a day if necessary, until pain is controlled. Patients transferring from morphine: base dosing requirements on 20mg of oral morphine being equivalent to 10mg of oxycodone. Adjust according to individual patient needs.

Special Care

Debilitated patients, liver and kidney disease, acute alcoholism, low blood pressure, pancreatitis, low circulating blood volume, underactive thyroid gland, enlarged prostate gland, raised pressure within skull, biliary tract disease, patients having had abdominal operations, inflammatory bowel disorders.

Avoid Use

Children, pregnancy, breastfeeding, head injured patients, depressed respiration, asthma, obstructive airways disease, acute abdomen, paralytic ileus, chronic constipation, moderate or severe liver disease, severe kidney disease, hypercarbia, delayed emptying of stomach, within 24 hours before and after surgery.

Possible Drug and Food Interactions

Anaesthetics, erythromycin, MAOIS, cimetidine, depressants of central nervous system, muscle relaxants, ketoconazole, quinidine, antihypertensives, alcohol.

Known Side Effects

Headache, gastrointestinal upset, itching, nettle rash, constipation, drowsiness, weakness, sweating; tolerance and dependence can develop. Any adverse side effects should be reported to the Committee on the Safety of Medicines (CSM).