Progynova TS

What is it?

An hormonal, oestrogen preparation available as skin patches in 2 strengths, releasing 50µg or 100µg of oestradiol per 24 hours.

Medical Uses

Symptoms of the menoperues, prevention of osteoporosis after the menopause.

Dosage

1 patch should be adhered to clean, non-hairy area of skin below level of waist and replaced every week, using fresh site. Start with 50µg patch and increase to 100µg, if required. In women who have not had a hysterectomy, a progestogen should be taken for last 10 to 12 days of month.

Special Care

High blood pressure, severe kidney disease receiving dialysis, Raynaud's disease, diabetes, multiple sclerosis, asthma, varicose veins, elevated levels of prolactin (a hormone) in the blood (hyperprolactinemia). Risk of thrombosis increases with smoking, age and obesity. Blood pressure, breasts and pelvic organs should be checked during period of treatment.

Avoid Use

Pregnancy, heart and circulatory diseases, angina, sickle cell anaemia, pulmonary hypertension. Also, hormone-dependent cancers, undiagnosed vaginal bleeding, chorea, liver disease, history of cholestatic jaundice of pregnancy, infectious hepatitis, Dublin-Johnson syndrome, Rotor syndrome, recent trophoblastic disease.

Possible Drug and Food Interactions

Phenytoin, carbamazepine, tetracyclines, primidone, chloral hydrate, glutethimide, phenylbutazone, rifampicin, griseofulvin, ampicillin, dichloralphenazone, ethosuximide, barbiturates, St John's Wort.

Known Side Effects

Feeling of bloatedness due to fluid retention, leg pains, breast enlargement, erosion of cervix, muscular cramps, weight gain, breakthrough bleeding, depression, headaches, vaginal discharge, loss of libido, nausea, brown patches on skin (chloasma). Stop drug immediately in event of pregnancy.