Prothiaden

What is it?

A TCAD preparation available as brown/red capsules containing 25mg of dothiepin hydrochloride marked P25. Also, PROTHIADEN TABLETS, sugar-coated red tablets containing 75mg of dothiepin hydrochloride, marked P75.

Medical Uses

Depression and anxiety

Dosage

Adults, 75 to 150mg each day either as divided doses or taken as single dose at night. Elderly patients, 50 to 75mg each day increasing slowly, if required, but only under strict medical advice.

Special Care

Patients with psychoses or suicidal tendencies, elderly persons, pregnant and nursing mothers, people with cardiac disorders, epilepsy, hyperthyroidism, urine retention, closed angle glaucoma, liver disease, tumours of adrenal gland, diabetes

Avoid Use

Children, patients with recent heart attack, heart arrhythmias, heart block, porphyria (rare blood disorder).

Possible Drug and Food Interactions

Alcohol, barbiturate drugs, local anaesthetics (containing adrenaline or noradrenaline), antihypertensive and sympathomimetic drugs, anticholinergic drugs, cimetidine, oestrogens.

Known Side Effects

Anticholinergic effects including urine retention, dry mouth, constipation, blurred vision, rapid heartbeat, palpitations, nervousness, insomnia, sweating, dizziness, fatigue, weight changes, jaundice, blood changes, allergic skin rashes, changes in libido, breast enlargement and impotence.

Manufacturer

Abbott.