Sinequan

What is it?

A TCAD preparation available as tablets in different strengths, all containing doxepin (as hydrochloride). Red capsules contain 10mg, coded SQN; red/blue contain 25mg, coded SQN 25; blue contain 50mg, coded SQN 50; blue/yellow contain 75mg, coded SQN 75.All are marked PFIZER.

Medical Uses

Depression.

Dosage

Adults, 10 to 100mg 3 times each day or a maximum of 100mg as a single bedtime dose.

Special Care

Patients with psychoses or suicidal tendencies, elderly persons, pregnant and nursing mothers, people with cardiac disorders, epilepsy, hyperthyroidism, urine retention, closed angle glaucoma, liver disease, tumours of adrenal gland, diabetes

Avoid Use

Children, patients with recent heart attack, heart arrhythmias, heart block, porphyria (rare blood disorder).

Possible Drug and Food Interactions

Alcohol, barbiturate drugs, local anaesthetics (containing adrenaline or noradrenaline), antihypertensive and sympathomimetic drugs, anticholinergic drugs, cimetidine, oestrogens.

Known Side Effects

Anticholinergic effects including urine retention, dry mouth, constipation, blurred vision, rapid heartbeat, palpitations, nervousness, insomnia, sweating, dizziness, fatigue, weight changes, jaundice, blood changes, allergic skin rashes, changes in libido, breast enlargement and impotence

Manufacturer

Pfizer.