Synflex

What is it?

An NSAID and propionic acid, available as blue tablets containing 275mg of napoxen sodium marked SYNTEX.

Medical Uses

Period pain, pain following operations, migraine, acute gout, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, other disorders of the skeleton and muscles.

Dosage

Adults and children aged over 16 years, usual dose, period pain and gout, usually 2 at start then 1 tablet every 6 to 8 hours, as needed but with a maximum of 4 each day on subsequent days. Musculoskeletal disorders, arthritis, ankylosing spondylitis and post-operative pain, 2 tablets twice each day. Migraine, 3 tablets as first dose then 1 or 2 tablets 6 to 8- hourly with a daily maximum of 5.

Special Care

Pregnancy, breastfeeding, elderly, liver or kidney disorders - monitoring required if drug taken long-term, history of lesions in gastrointestinal tract, heart failure, asthma. Patients taking drug long-term require careful monitoring, as do patients with coagulation disorders.

Avoid Use

Children under 16 years, known allergy to NSAID or aspirin, previous or current stomach ulcer.

Possible Drug and Food Interactions

Sulphonylureas, corticosteroids, cardiac glycosides, anticoagulants, frusemide, β-blockers, quinolones, mifepristone, ACE inhibitors, cyclosporin, hydantoins, lithium probenecid, methotrexate.

Known Side Effects

Blood changes, headache, gastrointestinal intolerance, vertigo, rash, tinnitus.

Manufacturer

Roche.