Zamadol SR

What is it?

An analgesic, opiate analogue available as sustained-release capsules in 4 strengths all containing tramadol hydrochloride, dark green, contain 50mg; white, contain 100mg; dark green, contain 150mg; yellow, contain 200mg. All marked with strength and TSR. Also, ZAMADOL, white capsules containing 50mg of tramadol hydrochloride. Also, ZAMADOL INJECTION, a solution in ampoules containing 50mg of tramadol hydrochloride per ml.

Medical Uses

Moderate to severe pain.

Dosage

Adults, Zamadol SR, 50 to 100mg to start twice each day then increase dose to 150 to 200mg twice each day, if needed. The daily maximum is 400mg. Zamadol, 1 or 2 capsules every 4 to 6 hours to a daily maximum of 8.Injection, 50 to 100mg by slow intravenous injection or intramuscular injection every 4 to 6 hours to a daily maximum of 600mg.

Special Care

Elderly, head injury, depression of respiration, previous fits, history of drug abuse or dependence, raised pressure within skull, severely impaired kidney or liver function.

Avoid Use

Children, pregnancy, breastfeeding.

Possible Drug and Food Interactions

SSRIs, depressants of CNS, alcohol, TCADs, carbamazepine, MAOIs.

Known Side Effects

Itching, allergic reactions, nettlerash, effects on CNS, profuse sweating, gastrointestinal upset. In rare cases, fainting, flushing, fits, rash, blurred vision, difficulty/disorder in passing urine, depressed respiration, effects on heart circulation, anaphylaxis, blood changes, depression and anguish, dependence.