Zanaflex

What is it?

A central 12-agonist available as white tablets in 2 strengths containing 2mg and 4mg of tizanidine as hydrochloride.

Medical Uses

Spasticity caused by disease or injury to the spinal cord or multiple sclerosis.

Dosage

Adults, 2mg to start then increasing at 3 to 4 day intervals by 2mg increments, according to response, to a daily amount of approximately 24mg in divided doses. The daily maximum is 36mg in divided doses.

Special Care

Pregnancy, breastfeeding, impaired kidney function. Liver tests should be performed for first 4 months and drug withdrawn if enzymes rise to 3 times normal levels.

Avoid Use

Children, elderly, impaired liver function.

Possible Drug and Food Interactions

Oral contraceptives, digoxin, depressants of CNS, diuretics, β-blockers, drugs that prolong QT interval (a part of the ECG), antihypertensives.

Known Side Effects

Gastrointestinal upset, slow heartbeat, drowsiness, low blood pressure, dizziness, insomnia, dry mouth, a rise in liver enzymes, fatigue, hallucinations, acute hepatitis.